Profhilo and Rejuran appear to be quite similar at first look, as they both produce the same effects:

  • Enhanced skin regeneration and rejuvenation
  • increased hydration
  • Getting rid of fine lines and wrinkles

Their parallels, however, cease there. The following are some of the critical distinctions between the two treatments.

Profhilo and Rejuran work through different methods.

Because Profhilo and Rejuran contain various active ingredients, they work through separate processes in the skin.

Rejuran promotes cellular skin regeneration by boosting fibroblast and skin tissue proliferation and directly delivering DNA building blocks. In addition, increased fibroblast activity stimulates the formation of collagen and glycosaminoglycans. All of these things help in skin regeneration.

Profhilo, on the other hand, operates on a different level. Profhilo, unlike Rejuran, goes lower down the metabolic process by directly delivering hyaluronic acid (HA) to dermal tissue. This implies that Profhilo has a more immediate effect on the skin in terms of hydration and sagging reduction. However, this means that Profhilo has a more limited yet specialised range of impact.

Profhilo and Rejuran can be used to treat a variety of ailments.

As previously stated, Profhilo and Rejuran have certain similarities in their effects. However, because they work through distinct pathways, they acquire these effects at different scales/intensities and are appropriate for treating diverse illnesses.

Rejuran works by inhibiting fibroblast proliferation and growth factors. As a result, it has better skin regeneration and healing benefits than Profhilo. Rejuran can cure moderate acne scars and decrease pores in some circumstances, which Profhilo is unlikely to do. Furthermore, Rejuran can thicken the skin’s protective layer, making it less vulnerable to damaging environmental impacts. Again, this is a feature that Profhilo lacks.

Profhilo, on the other hand, directly delivers HA to dermal tissue. As a result, it is more effective in hydrating the skin. Profhilo’s bioremodeling actions can also offer a general lifting impact to the face, minimising sagging skin, which Rejuran is less efficient at. Profhilo is, therefore, more appropriate for people with dry, sagging skin.

Profhilo and Rejuran have various injection protocols/methods.

Although both Profhilo and Rejuran are injected into the skin, their treatment procedures and injection techniques are highly different.

Profhilo is injected into ten strategically chosen points on the lower regions of the face (the cheekbones and below), with five points on each side or the neck. 0.2ml of Profhilo is injected at each location. The product is then distributed by gently massaging the face. This indicates that Profhilo mainly operates on the lower portions of the face or the neck. It is theoretically conceivable to employ Profhilo on the top areas of the face, but it is not done in reality because no protocol has been devised for this. Profhilo therapy typically consists of two initial sessions one month apart, followed by single treatments every six months thereafter.

Rejuran injections, on the other hand, is often administered by a series of micro-injections into various regions of the face. This can be done manually or, preferably, using a precision-controlled injector gun. Rejuran, unlike Profhilo, may be given to all sections of the face. Unlike Profhilo, the suggested treatment schedule for Rejuran includes three initial sessions one month apart, followed by six monthly single sessions.

Can I combine Profhilo with Rejuran?

Profhilo and Rejuran can undoubtedly be coupled into a more comprehensive treatment plan. In fact, since they operate through separate systems, they have a synergistic impact on one another. Nonetheless, we should visit our doctors about this because each person may have distinct underlying issues preventing them from receiving any of these medicines.


Both Rejuran and Profhilo are excellent injectable skin treatments for aged skin. Although the two have some similarities, they are drastically different when examined attentively. In fact, their contrasts help them to work effectively together.